荒木飛呂彥的新替身XD
真是夠了XD
http://www.cell.com/content/issue?volume=130&issue=5
原文如下
On the cover: Presynaptic plasticity is a fundamental, yet poorly understood, neural phenomenon that is thought to be the basis of learning and memory. In this issue, Yao et al. (pp. 943–957) identify a novel ubiquitin ligase named SCRAPPER, which is responsible for tuning of synaptic vesicle release probability. SCRAPPER ubiquitinates presynaptic active zone protein RIM1, triggering its proteasomal degradation. Neurons from the Scrapper-knockout mice have hyper electrophysiological activity and contained increased amount of RIM1, and these phenotypes could be rescued by re-expression of SCRAPPER or knockdown of RIM1. The results highlight the importance of protein degradation in the regulation of synaptic activity in vivo. On the cover, the purple SCRAPPER humanoid is putting blue heart-shaped ubiquitins on the red RIM creatures. Japanese manga artist Hirohiko Araki created the cover image with scientific direction from Drs. Setou and Ageta.
原來被替身化的ubiquitin ligase長這樣XD
"歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉"
"沒用沒用沒用沒用沒用沒用沒用沒用沒用沒用沒用"
看來神經細胞裡會很熱鬧呢
http://www.cell.com/content/issue?volume=130&issue=5
原文如下
On the cover: Presynaptic plasticity is a fundamental, yet poorly understood, neural phenomenon that is thought to be the basis of learning and memory. In this issue, Yao et al. (pp. 943–957) identify a novel ubiquitin ligase named SCRAPPER, which is responsible for tuning of synaptic vesicle release probability. SCRAPPER ubiquitinates presynaptic active zone protein RIM1, triggering its proteasomal degradation. Neurons from the Scrapper-knockout mice have hyper electrophysiological activity and contained increased amount of RIM1, and these phenotypes could be rescued by re-expression of SCRAPPER or knockdown of RIM1. The results highlight the importance of protein degradation in the regulation of synaptic activity in vivo. On the cover, the purple SCRAPPER humanoid is putting blue heart-shaped ubiquitins on the red RIM creatures. Japanese manga artist Hirohiko Araki created the cover image with scientific direction from Drs. Setou and Ageta.
原來被替身化的ubiquitin ligase長這樣XD
"歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉歐拉"
"沒用沒用沒用沒用沒用沒用沒用沒用沒用沒用沒用"
看來神經細胞裡會很熱鬧呢

